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Study Of The Intermediary Metabolic Pathways Of 1,1-Dimethylhydrazine (UDMH)

Report Number: AMRL TDR 62-110
Author: Mitz, Milton A.
Author: Aldrich, F. L.
Author: Vasta, B. M.
Corporate Author: Melpar Inc Falls Church VA
Laboratory: Biomedical Laboratory
Date of Publication: 1962-09
Pages: 26
Contract: AF 33(616)-8455
Project: 6302
Task: 630202
AD Number: AD0290509

The metabolic fate of 1,1-dimethylhydrazine (UDMH) was studied in female rats and dogs. The animals were given intraperitoneal injections of C14 labelled UDMH and, after an appropriate time, body tissues were examined by paper chromatography. Six compounds were found, although not all appeared in every tissue. Three major compounds were present in urine. Identification showed one (3-10%) to be the glucose hydrazone of UDMH, and another appeared to be unreacted UDMH (50-60%). The structure of the third major component (20-25%) was not determined, although its chemical and chromatographic behavior suggested that it was a hydrazone or hydrazide of a compound of higher molecular weight than acetic or pyruvic acid. Various analytical procedures were employed for the determination of UDMH in urine, and the trisodium pentacyanoaminoferroate (TPF) procedure was found to be the most sensitive and most specific qualitative method of those tested.

Lockheed Martin Missiles & Fire Control
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