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Pharmacology And Toxicology Of 1,1-Dimethyl-Hydrazine (UDMH)

Report Number: AMRL TDR 62-118
Author: Back, Kenneth C.
Author: Thomas, Anthony A.
Corporate Author: Aerospace Medical Research Labs Wright-Patterson AFB Ohio
Laboratory: Biomedical Laboratory
Date of Publication: 1962-10
Pages: 12
Contract: Laboratory Research - No Contract
Project: 6302
Task: 630202
AD Number: AD0292689

The acute LD50 of UDMH in mice, rats, dogs and monkeys by intraperitoneal administration was found to be 125 mg/kg, 104 mg/kg, 60-100 mg/kg, and 60-100 mg/kg, respectively. All animals exhibited clonic-tonic convulsions as the predominant symptom, and death was via respiratory arrest. Dogs and monkeys routinely showes emesis within 15-60 minutes following dose of UDMH, regardless of rout. In the anesthetized dog UDMH did not alter the effects of epinephrine, norepinephrine, acetylcholine, histamine, or resperine on blood pressure. It did not significantly affect autonomic ganglia or postganglionic nerve endings, nor did it markedly alter the electrocardiogram or blood pressure in 1-2 hours. In the unanestetized dog, however, blood pressure was significantly increased until convulsions and respiratory arrest occurred.

Lockheed Martin Missiles & Fire Control
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