Contrails
The goal of the Contrails project is to help preserve and disseminate the technical record of 20th century aerospace research, highlighting in particular the research endeavors of the Illinois Tech community.

Pathology and Toxicology of Repeated Doses of Hydrazine and 1,1-Dimethylhydrazine in Monkeys and Rats

Report Number: AMRL TDR 64-43
Author: Patrick, Roman L.
Author: Back, Kenneth C.
Corporate Author: Biomedical Laboratory
Laboratory: Biomedical Laboratory
Date of Publication: 1964-06
Pages: 18
Contract: Laboratory Research - No Contract
Project: 6302
Task: 630201
AD Number: AD0604525

Abstract:
Twelve rhesus monkeys received daily doses of hydrazine ranging from 5 to 20 mg/kg and totaling from 4 to 20 injections. Seven monkeys received 20 injections of 1, 1-dimethylhydrazine at 10 mg/kg. All animals lost weight during the experiment. In the hydrazine-treated group of monkeys, serum glutamic oxaloacetic transaminase and bilirubin rose with doses of 20 mg/kg, with more than a twentyfold increase of SGOT in two animals. Most of those receiving 20 mg/kg exhibited loss of appetite, vomiting, lethargy, and severe weakness. Microscopic examination revealed lipid accumulation in the liver, myocardium, kidney, and skeletal muscle. Massive liver necrosis was observed in one animal. In those monkeys receiving UDMH, blood glucose rose significantly toward the end of the experiment. Some lipid was deposited in the heart, liver, and kidney, but to a much lesser degree than was observed with hydrazine, and it could only be demonstrated with special fat stain. Rats given from 3 to 23 doses of 10 or 20 mg/kg/day hydrazine did not show marked fatty changes as observed in the monkeys.


Provenance:
RAF Centre of Aviation Medicine
Download this report

(PDF, 0.74 MB, 18 pages)

Other options for obtaining this report

Via the Defense Technical Information Center (DTIC):
A record for this report, and possibly a full-image download of the report, exists at DTIC

Via National Technical Information Service:
This report may have been digitized and made freely available for public download, or made publicly available for purchase by the National Technical Information Service through their online database, the National Technical Reports Library

Indications of Public Availability
No digital image of an index entry indicating public availability is currently available
The inside cover of this report indicates that it was released for public sale
The original price to the public, according to the cover, was 0.5