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Screening of New Chelating Agents for Beryllium

Report Number: AMRL TR 65-135
Author: Sterner, Wolfgang
Author: Loveless, L. E.
Corporate Author: International Bio-Research, Inc.
Laboratory: Aerospace Medical Research Laboratories
Date of Publication: 1965-08
Pages: 30
Contract: AF 33(615)-1804
Project: 6302
Task: 630202
AD Number: AD0623321

Thirteen polyaminopolycarboxylic acid chelating agents were evaluated in vitro and in vivo as potential therapeutic agents for acute beryllium poisoning. In the in vitro test system the ability of the chelating agent to reverse beryllium induced inhibition of alkaline phosphate was measured. In the in vivo system, the chelating agent was evaluated by its ability to prevent mortality of rats that had received an acute lethal dose of beryllium sulfate. None of the polyaminopolycarboxylic acids reversed completely the inhibition of alkaline phosphatase at either 35 percent or 65 percent levels of inhibition. All compounds were ineffective in overcoming the toxic dose of beryllium in rats.

RAF Centre of Aviation Medicine
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