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The goal of the Contrails project is to help preserve and disseminate the technical record of 20th century aerospace research, highlighting in particular the research endeavors of the Illinois Tech community.

1, 1-Dimethylhydrazine Effects on Central Excitatory and inhibitory Mechanisms in Cats

Report Number: AMRL TR 65-142
Author(s): M. D. Fairchild; M. B. Sterman
Corporate Author: University of California, Los Angeles
Laboratory: Aerospace Medical Research Laboratories
Date of Publication: 1965-08
Pages: 39
Contract: AF 41(609)-2329
Project: 6302
Task: 630202
AD Number: AD0623786

Abstract:
Experiments, using cats with chronically implanted brain electrodes, were performed to explore the influence of subconvulsive doses of 1, 1- dimethylhydrazine (UDMH) on certain excitatory and inhibitory mechanisms in the central nervous system (CNS). The cats were stimulated electrically in the midbrain reticular activating system, the basal forebrain inhibitory area, and both areas simultaneously while the animal was tested for performance in a positively reinforced experimental situation. UDMH was compared with amphetamine, chlorpromazine and phenobarbital both in the presence and absence of CNS stimulation. UDMH acted in a manner similar to chlorpromazine in subconvulsive doses in these tests. The most interesting and consistent effect of UDMH was to abort performance when the basal forebrain inhibitory area was stimulated. The animals resumed performance when the stimulus was terminated. UDMH has detectable CNS effects at doses well below convulsive levels.

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