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Pathology of Oxygen Toxicity in Forty Macaca Mulatta

Report Number: AMRL TR 66-234
Author: Robinson, Farrel R.
Author: Harper, David T.
Author: Kaplan, Harold P.
Author: Thomas, Anthony A.
Corporate Author: Biomedical Laboratory
Laboratory: Biomedical Laboratory
Date of Publication: 1967-03
Pages: 22
Contract: Laboratory Research - No Contract
Project: 6302
Task: 630206
AD Number: AD0653526

Forty monkeys (Macaca mulatta) were exposed to 99-100% oxygen at pressures from 600 to 760 mm Hg. The acute exudative pulmonary response was seen in only three exposed at 760 mm Hg. The subacute proliferative pulmonary response was seen at all levels studied, the degree being directly related to time-dose exposures. In the high dose ranges clinical signs of illness were evident after 5-7 days exposure when the monkeys became listless and anoretic. By 14 days they were quite lethargic and had assumed a huddled position. Grossly, the heavy lungs had a gray, bloodless appearance. Microscopically, there was extreme proliferation of the interstitium and alveolar epithelium. None of the monkeys that were exposed at 600 mm Hg died, although mild focal proliferative changes were seen. After 31 days postexposure, these changes appeared as focal areas of atelectasis with mild septal fibrosis.

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