Contrails
The goal of the Contrails project is to help preserve and disseminate the technical record of 20th century aerospace research, highlighting in particular the research endeavors of the Illinois Tech community.

Effect of Hydrazines on Vitamin B6 Levels in the Mouse Brain

Report Number: AMRL TR 66-135
Author(s): Arthur Furst; Waldemar R. Gustavson
Corporate Author: University of San Francisco
Laboratory: Aerospace Medical Research Laboratories
Date of Publication: 1966-09
Pages: 46
Contract: AF 33(615)-2332
Project: 6302
Task: 630202
AD Number: AD0647192

Abstract:
The effects of administered 1,1-dimethylhydrazine (UDMH) and monomethylhydrazine (MMH) on vitamin B6 levels in mouse brain have been studied. Separation of the B6 group (pyridoxol, pyridoxal, pyridoxamine, and the respective 5-phosphates) by means of paper chromatography revealed that the R sub F values obtained are dependent upon the pH of the developing solvent. To obtain the time lag just prior to convulsions induced by UDMH and MMH, a dose-lag time study was conducted; included were pyridoxal and (its 5-phosphate) hydrazones of UDMH and MMH. Graphs of log dose vs lag time are given. The bioassay procedure, though not completed, permits detection of some of the B6 congeners to a limit of 0.5 nanograms.

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