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Effect of Hydrazines on Vitamin B6 Levels in the Mouse Brain

Report Number: AMRL TR 66-135
Author: Furst, Arthur
Author: Gustavson, Waldemar R.
Corporate Author: University of San Francisco
Laboratory: Aerospace Medical Research Laboratories
Date of Publication: 1966-09
Pages: 46
Contract: AF 33(615)-2332
Project: 6302
Task: 630202
AD Number: AD0647192

The effects of administered 1,1-dimethylhydrazine (UDMH) and monomethylhydrazine (MMH) on vitamin B6 levels in mouse brain have been studied. Separation of the B6 group (pyridoxol, pyridoxal, pyridoxamine, and the respective 5-phosphates) by means of paper chromatography revealed that the R sub F values obtained are dependent upon the pH of the developing solvent. To obtain the time lag just prior to convulsions induced by UDMH and MMH, a dose-lag time study was conducted; included were pyridoxal and (its 5-phosphate) hydrazones of UDMH and MMH. Graphs of log dose vs lag time are given. The bioassay procedure, though not completed, permits detection of some of the B6 congeners to a limit of 0.5 nanograms.

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