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Subconvulsive Effects of 1, 1-Dimethylhydrazine on Locomotor Performance in the Cat: Relationship of Dose to Time of Onset

Report Number: AMRL TR 67-66
Author(s): M. B. Sterman; M. D. Fairchild
Corporate Author: University of California, Los Angeles
Laboratory: Aerospace Medical Research Laboratories
Date of Publication: 1967-09
Pages: 20
Contract: AF 33(615)-2822
Project: 6302
Task: 630202
AD Number: AD0664549

Several recent neurophysiological findings in the study of 1, 1- dimethylhydrazine toxicity have suggested that this substance initiates a gradual increase in central nervous system (CNS) excitability, leading eventually to general convulsions. This process, however, is periodically interrupted by episodes of recovery or suppression of excitability. In the present experiment an attempt was made to investigate the nature of this alternation in response to low doses of UDMH, using the performance of a locomotor task as a measure of CNS effects. Cats were trained and tested in a special runway apparatus to provide a reliable indication of performance changes over a 6 hour period following the administration of 4, 8, and 16 mg/kg UDMH. These low doses significantly altered locomotor performance in a predictable manner. The response to a given dose was both consistent and unique to that dose. Within the 6 hour period of measurement, 16 mg/kg caused a gradual reduction in performance velocity leading to a total disruption, which was then followed by a tendency to recover; 8 mg/kg produced a recurrent depression of velocity followed by an enhancement, and 4 mg/kg resulted in a biphasic depression facilitation response. Other more general findings are also discussed.

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