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Comparative Studies of 90-Day Continuous Exposure to O3, NO2 and CCl4 at Reduced and Ambient Pressures

Report Number: AMRL TR 67-68
Author: MacEwan, J. D.
Author: Geckler, R. P.
Corporate Author: Aerojet-General Corporation
Laboratory: Aerospace Medical Research Laboratories
Date of Publication: 1968-02
Pages: 67
Contract: AF 33(657)-11305
Project: 6302
Task: 630201
AD Number: AD0669079

Ninety-day continuous animal exposures to ozone, nitrogen dioxide and carbon tetrachloride at Threshold Limit Values (TLV) were conducted under ambient pressure and 100% oxygen-reduced pressure (5 psia) conditions. Four species, dogs, monkeys, rats, and mice were exposed to each material. Guinea pigs were also used for ozone exposures due to their reported susceptibility to this pulmonary irritant. Minimal biologic responses were observed with exposure to each of the compounds tested and, consequently, lower tentative exposure limits are recommended for space cabin environments. The recommended limits, based on the time period tested, are 1 ppm for nitrogen dioxide, 0.01 ppm for ozone, and 0.5 ppm for carbon tetrachloride.

RAF Centre of Aviation Medicine
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