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Oxygen Transport Through Hemoglobin Solutions

Report Number: AMRL TR 66-19
Author: Hammel, Harold T.
Corporate Author: John B. Pierce Foundation Laboratory
Laboratory: Aerospace Medical Research Laboratories
Date of Publication: 1966-02
Pages: 24
Contract: AF 33(657)-11103
Project: 7164
Task: 716409
AD Number: AD0635623

Scholander discovered that the steady state flux of oxygen through a thin film of water could be enhanced many times by adding hemoglobin to the water. Several authors have ascribed this facilitated flux of oxygen to the diffusion of oxyhemoglobin down its gradient although the details of their formulations have not been rigorously supported by experimental evidence. A series of measurements of oxygen and nitrogen flux through a film of hemoglobin solution were made for which the pO2 and pN2 on6ne side were always 16.5 and 62.5 mm Hg respectively while the pO2 on the other side was increased from 0.5 to 14 mm Hg by adding increasing thicknesses of teflon film to this side. When the facilitated oxygen flux was small, it was found to equal the calculated flux assuming that the oxygen was carried by the diffusing oxyhemoxglobin and that Henry's law and the equilibrium dissociation curve for oxyhemoglobin apply at the two surfaces of the hemoglobin film. When the facilitated oxygen flux was greatest, it was found to be only one half the calculated flux, presumably because the pO2 on the solution side of the gas-solution interface was considerably less than the 16.5 mmHg prevailing on the gas side.

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